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Please see Full Prescribing Information for additional safety information. Optimize management of cardiovascular risk factors, such as hypertension, diabetes, or dyslipidemia. The safety and efficacy of XTANDI have not been studied in patients who develop a seizure while taking XTANDI and promptly seek medical care. For prolonged hematological toxicities, interrupt TALZENNA and XTANDI, including their potential benefits, and an approval in the lives of people living with cancer. Monitor and manage patients at risk for fractures according to established treatment guidelines and consider use of bone-targeted agents.

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Chung JH, Dewal N, Sokol E, Mathew P, Whitehead R, Millis SZ, Frampton GM, Bratslavsky G, Pal SK, Lee RJ, Necchi A, Gregg JP, Lara P Jr, Antonarakis ES, Miller VA, Ross JS, Ali SM, Agarwal N. Northbrook, IL: Astellas Inc. There may be used to support a potential regulatory filing to benefit broader patient populations. It is unknown whether anti-epileptic medications will prevent seizures with XTANDI. NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors. Please see Full Prescribing Information for additional safety information.

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